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October 2, 2023

What Is A Clinical Pathologist? – An Introduction to Modern Pathology

  • May 21, 2022
  • 4 min read
What Is A Clinical Pathologist? – An Introduction to Modern Pathology

Clinical pathologists are specialized healthcare specialists that have experience in managing hospital laboratories and independent diagnostic laboratories. They have general knowledge of illness diagnosis, prevention, and therapy and more specific knowledge in laboratory testing. They are in charge of all specialized departments such as hematology, toxicology, and microbiology. They also handle immunology (including histocompatibility matching for organ transplantation), serology, blood banking, clinical chemistry, and microbiology. Clinical pathologists also manage research data to keep quality control and information system records up to date.

Clinical pathologists are also physicians who specialize in the field of diagnosis and illness management using laboratory tests based on research. They are an important element of the treatment procedures since they are in charge of supplying reliable information about the patients through the examination of their blood and tissue samples. During the course of therapy, patients will never visit a clinical pathologist who work behind the scenes to ensure accurate laboratory testing.

Pathology is the study or learning of illnesses; it bridges the gap between medicine and basic science. It aids in precisely diagnosing the patient’s condition, and medicine (for example the correct antibiotics for an infection) is administered appropriately. In the past few decades, Clinical Pathology laboratories have expanded their role in disease diagnosis and treatment by offering genetic testing for inherited diseases and screening for tumor markers that direct cancer therapy.

Legendary Pathologist: DR PAUL ERNEST LOVE 

Immunology facts and information are attributed to recognized experts and scientists such as Paul E. Love, MD, PhD, a Clinical Pathologist and researcher. He works as an investigator at the National Institutes of Health (NIH) in the United States. Love has made tremendous advances in comprehending the mammalian immune system’s intricacy. His contributions are mostly concerned with the involvement of immune receptor-tyrosine-based activation motifs (ITAMs) which are essential for activation of immune cells and their ability to combat pathogens and tumor cells. T cells, one of the lymphocyte types required to combat infectious diseases and cancer, utilize ITAMs for activation by antigens. T cells also monitor malignancies and are an essential component of the body’s surveillance for cancer cells.

Treatments for autoimmune illnesses are now possible, thanks to advances in immunology research. The National Institutes of Health (NIH) is widely regarded for its research and studies that have resulted in significant advances in healthcare. Paul E. Love is a well-known investigator at the core of the NIH, whose skill and experience in the field of immunology have resulted in notable discoveries.

Love is also widely known for establishing approaches and providing crucial discoveries that have directly contributed to the development of specialized medicines that may be useful for the treatment of autoimmune illnesses and cancer.

Dr. Paul Love acquired a B.S. in Biochemistry from Syracuse University, as well as an M.D. and Ph.D. from the University of Rochester’s Medical Science Training Program (MSTP). Before performing post-doctoral research at NIH, he completed a residency in Laboratory Medicine (Clinical Pathology) at Washington University in St. Louis and a fellowship in Human Genetics at the Eunice Kennedy Shriver, National Institute of Child Health and Human Development (NICHD). In 1993, he became an intramural Principal Investigator, and he is currently a tenured Senior Investigator and the director of the NICHD Section on Hematopoiesis and Lymphocyte Biology.

Dr. Love’s lab’s research interests are in mammalian hematopoiesis. The lab has a long history of investigating T cell development, which begins with the migration of multipotent progenitor cells to the thymus from hematopoietic stem cells in the bone marrow. Immature T cells then go through a series of developmental steps in the thymus, including a selection process that promotes the development of functional cells while deleting overtly self-reactive cells, eventually leading to the generation of mature “self-tolerant” T lymphocytes that exit the thymus and populate the peripheral lymphoid organs. Over the years, Dr. Love’s research has explored questions related to each of these phases in the T cell developmental process and his recent studies have centered on applying the insights learned about T cell function to cancer immunotherapy.


Clinical pathologists are in charge of the laboratory’s particular sections, where they supervise and ensure the accuracy of laboratory testing used in medicine. Clinical pathology studies take around four years to complete after medical school. Residents in Clinical Pathology attend training sessions where they learn all of the newest tools and types of equipment that aid in the diagnosis of disease by laboratory testing, including genetic testing. A qualified pathologist will assist you in determining the actual source of the illnesses and perform tests that assist in choosing the correct medical treatment.